PhD Studentship in Molecular and Cellular Evaluation of Biomarkers of Response to Therapy in Rectal Cancer Patients
Barts and The London -Centre for Digestive Diseases Blizard Institute of Cell and Molecular Science (BICMS)
Project Title: Molecular and cellular evaluation of biomarkers of response to therapy in rectal cancer patients
Supervisor: Professor Andrew Silver Co-Supervisor: Dr Cleo Bishop
Applications are invited from Biology/Biochemistry graduates with a BSc (First or Upper Second) or MSc (Distinction or Merit). Previous research experience would be an advantage This 3 year studentship will commence in July 2014 and the applicant will be based in the School’s Whitechapel Campus
This project aims to identify new biomarkers to distinguish rectal cancers likely to be refractory to neoadjuvant therapy, thereby sparing these patients unnecessary treatment and associated morbidity. The study may also uncover novel targets more suitable for therapy in patients unresponsive to current therapies. One particular feature of rectal cancer that can limit treatment success is hypoxia. We have linked hypoxic changes in rectal cancer cells to alterations in the expression key microRNAs, metabolites and pivotal members of the NADPH oxidase gene family. This multidisciplinary studentship will investigate the molecular mechanisms behind these changes and assess the utility of biomarkers of hypoxia and treatment response in patients. The project will involve collaboration with Dr Ricky Sharma, Department of Oncology, University of Oxford and there will be an opportunity to spend time in Dr Sharma’s laboratory.
The project will provide training in a range of molecular and cellular techniques and involve interaction with clinical and scientific colleagues in a highly collaborative and friendly environment. There will be access to a wide variety of cutting-edge technologies and state-of-the-are core facilities, as well as interaction with leading international researchers across a wide range of biomedical disciplines. Training will also be given in a number of transferable skills.
Informal enquires to Professor Andrew Silver (email@example.com) or Dr Cleo Bishop (firstname.lastname@example.org)
This Studentship is sponsored by the Constance Travis Charitable Trust and comes with a minimum tax free stipend of £15,726.00 per annum. It is open to UK Nationals, EEA/Swiss migrant workers and non-UK nationals with indefinite leave to remain in the UK who all have three years ordinary residence in the UK prior to the start of the studentship.
Closing date for applications is 31st March 2014.
PhD Studentship in Skin Immune Cell Interactions in Health and Disease
The University of Manchester -Manchester Collaborative Centre for Inflammation Research
Professor Tracy Hussell and Dr Amy Saunders
The Manchester Collaborative Centre for Inflammation Research (MCCIR) invites applications for a 3-year funded PhD due to commence October 2014. The studentship covers UK/EU tuition fees, research expenses and annual tax-free stipend of £17,000. The studentship is open to UK/EU nationals only due to the nature of the award.
The skin is one of the largest organs in the body and functions as a barrier to prevent the loss of substances and to prevent infection. To fulfil this role the skin harbours a wide range of immune cells poised to combat any invading pathogens. The lung and gut are other barrier sites and have been the focus of study for many immunologists in recent years yet surprisingly little is known about the skin immune system particularly in healthy individuals. We have recently identified that in the lung the default state of innate immune cells is to be actively restrained by signals from healthy tissue (Snelgrove, 2011) but as yet, there are little data in skin.Psoriasis is a highly prevalent inflammatory skin disease in which a wide range of immune cells are implicated (Griffiths, 2003; Griffiths, 2006). However, prior research has not focussed on cell to cell interactions. This project addresses the hypothesis that psoriasis is maintained due to a lack of regulatory mechanisms usually present in health. The PhD will analyse the contribution of these regulatory pathways to psoriasis in human skin explants and the mechanisms involved will also be explored using murine models. Training offers the opportunity to work on clinically relevant human disease and will include techniques such as flow cytometry, quantitative PCR, histology, murine models of inflammatory skin disease and human explant cultures.
This project will be hosted within the MCCIR. MCCIR is a partnership between the University of Manchester, AstraZeneca and GSK, allowing the successful applicant to gain an insight into applied research in industry. Ideal candidates will have a strong interest in immunology/dermatology and hold relevant laboratory experience.
Candidates are expected to hold a minimum upper-second (or equivalent) undergraduate degree in a relevant biological/medical science area such as immunology, dermatology and/or biochemistry. They must also have some prior laboratory experience, ideally involving some of the techniques to be employed in this project. A Masters qualification in a similar area would be an advantage.
Official academic transcripts
Contact details for two suitable referees
A personal statement (750 words maximum) outlining your suitability for the study, what you hope to achieve from the PhD and your research experience to date.
Any enquiries relating to the project and/or suitability should be directed to Dr Saunders at the address above. Deadline for applications: Friday 21 February 2014.
Clinical Research PhD Fellowship
University of Edinburgh -Centre for Cancer Research
£31,838 – £47,175
Funded by a Cancer Research UK Fellowship, this post provides doctoral training in an internationally renowned research environment in the MRC Centre for Reproductive Health (adjacent to the Royal Infirmary of Edinburgh). The Fellow will work on a project focussing on strategies for early diagnosis and treatment of endometrial cancer addressing key research questions. The post is funded for 3 years leading to a PhD. Appointees will be highly motivated clinicians with an interest in pursuing an academic career. Possession of necessary clinical qualifications to enter a specialist training programme in their chosen medical speciality is essential. Research experience is desirable, but not essential.
Informal enquiries to Professor Philippa Saunders: email@example.com.
Closing Date: 3 March 2014